If you’ve seen Bong Joon-ho’s film Okja, about an AgribusiÂness-engiÂneered garÂganÂtuÂan mutant pig and her young KoreÂan girl sideÂkick, you may have some very speÂcifÂic ideas about CRISPR, the sciÂence used to edit and manipÂuÂlate genes. In fact, the madÂcap ficÂtionÂal adventure’s world may not be too far off, though the sciÂence seems to be movÂing in the othÂer direcÂtion. Just recentÂly, ChiÂnese sciÂenÂtists have reportÂed the creÂation of 12 pigs with 24 perÂcent less body fat than the ordiÂnary variÂety. It may not be front-page news yet, but the achieveÂment is “a big issue for the pig indusÂtry,” says the lead researcher.
There’s much more to CRISPR than bioÂengiÂneerÂing lean bacon. But what is it and how does it work? I couldn’t begin to tell you. Let biolÂoÂgist Neville SanÂjana explain. In the Wired video above, he underÂtakes the ultiÂmate chalÂlenge for sciÂence communicators—explaining the most cutÂting-edge sciÂence to five difÂferÂent peoÂple: a 7‑year-old, 14-year-old, colÂlege stuÂdent, grad stuÂdent, and—to realÂly put him on the spot—a CRISPR expert. CRISPR is “a new area of bioÂmedÂical sciÂence that enables gene editÂing,” SanÂjana begins in his short intro for viewÂers, “and it’s helpÂing us underÂstand the basis of many genetÂic disÂeases like autism and canÂcer.”
That’s all well and good, but does he have anyÂthing to say about the pig busiÂness? Watch and find out, beginÂning with the adorable 7‑year-old Teigen RivÂer, who may or may not have been primed with perÂfect responsÂes. Play it for your own kids and let us know how well the explaÂnaÂtion works. SanÂjara runs quickÂly through his othÂer stuÂdents to arrive, halfway through the video, at Dr. Matthew CanÂver, CRISPR expert.
From there on out you may wish to refer to othÂer quick refÂerÂences, such as the HarÂvard and MIT Broad Institute’s short guide and video intro above from molÂeÂcÂuÂlar biolÂoÂgist Feng Zhang, who explains that CRISPR, or “ClusÂtered RegÂuÂlarÂly InterÂsperced Short PalinÂdromic Repeats,” is actuÂalÂly the name of DNA sequences in bacÂteÂria. The gene editÂing techÂnolÂoÂgy itself is called CRISPR-Cas9. Just so you know how the sausage is made.
Enough of pig puns. Let’s talk about brains, with neuÂroÂsciÂenÂtist Dr. BobÂby Kasthuri of the Argonne NationÂal LabÂoÂraÂtoÂry. He faces a simÂiÂlar chalÂlenge above—this time explainÂing high conÂcept sciÂence to a 5‑year-old, 13-year-old, colÂlege stuÂdent, grad stuÂdent, and a “ConÂnecÂtome entreÂpreÂneur.” A what? ConÂnecÂtome is the prodÂuct of the NIH’s Human ConÂnecÂtome Project, which set out to “proÂvide an unparÂalÂleled comÂpiÂlaÂtion of neurÂal data” and “achieve nevÂer before realÂized conÂcluÂsions about the livÂing human brain.” This brain-mapÂping sciÂence has many objecÂtives, one of which, in the 5‑year-old verÂsion, is “to know where every cell in your brain is, and how it can talk to every othÂer cell.”
To this astonÂishÂing explaÂnaÂtion you may reply like Daniel DodÂson, 5‑year-old, with a stunned “Oh.” And then you may think of Philip K. Dick, or Black MirÂror’s “San Junipero” episode. EspeÂcialÂly after hearÂing from “ConÂnecÂtome EntreÂpreÂneur” RusÂsell HanÂson, founder and CEO of a comÂpaÂny called Brain BackÂups, or after lisÂtenÂing to SebasÂtÂian Seung—“leader in the field of connectomics”—give his TED talk, “I am my conÂnecÂtome.” Want anothÂer short, but grown-up focused, explaÂnaÂtion of the totalÂly sciÂence-ficÂtion but also comÂpleteÂly real ConÂnecÂtome? See Kasthuri’s 2‑minute aniÂmatÂed video above from Boston UniÂverÂsiÂty.
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Josh Jones is a writer and musiÂcian based in Durham, NC. FolÂlow him at @jdmagness